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The Truth About GLP-1: Weight Loss, Medications, and Side Effects

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Health with Hashimoto’s is your free weekly podcast to explore the root causes of your autoimmune condition and discover holistic solutions to address your Hashimoto’s thyroiditis.

[/fusion_title][fusion_text animation_direction=”left” animation_speed=”0.3″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky”]

You will find this episode below in audio format and a written summary because I know not everyone is an audio learner. Some links may be affiliate links that will support me without increasing your price.

Each episode of Health with Hashimoto’s is for informational and educational purposes. Please discuss any questions or concerns with your trusted healthcare professional.

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The Holistic Hashimoto’s Course

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Recharge Your Energy and Banish Overwhelm

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Your journey back to feeling like yourself again starts here.

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Watch: GLP-1 weight loss medications side effects

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link=””][fusion_title title_type=”text” rotation_effect=”bounceIn” display_time=”1200″ highlight_effect=”circle” loop_animation=”off” highlight_width=”9″ highlight_top_margin=”0″ title_link=”off” link_target=”_self” content_align=”left” size=”2″ text_shadow=”no” text_shadow_blur=”0″ gradient_font=”no” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ style_type=”default” animation_direction=”left” animation_speed=”0.3″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky”]

Mentioned on This Episode:

[/fusion_title][fusion_text animation_direction=”left” animation_speed=”0.3″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky”]

Related Episodes:

079 // Hashimoto’s and weight loss medications like Semaglutide and Ozempic

Articles/Studies:

Comparison Chart from Diabetes Daily

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GLP-1 Weight Loss Medications & Side Effects

[/fusion_title][fusion_text hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” animation_direction=”left” animation_speed=”0.3″]Many women with Hashimoto’s struggle to lose weight, despite doing all the right things—eating healthy, exercising, sleeping well, and drinking enough water. If you’re one of these women, you’re not alone. You may have 10, 15, or even 50 pounds you’d like to release, and you’re searching for hope.

Medications like Wegovy, Ozempic, and Mounjaro promise better blood sugar and weight loss. The question is: Are these the right option for you?

What Are GLP-1 Agonists?

GLP-1 agonists are a type of medication that’s gained significant popularity, with about 6% of people in the US trying them. But what are they, and could they be the right choice for you? While these medications have been widely used, it’s essential to weigh the benefits against the risks. Fortunately, there are also natural ways to increase your GLP-1 hormone.

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This is the first episode in a series on GLP-1. In this episode, we’ll focus on GLP-1, weight loss, and medications.

In the next episode, we’ll explore how you can naturally increase your GLP-1.

The third episode will discuss a simple system for boosting GLP-1 to support hormone balance and weight loss.

What is GLP-1?

GLP-1 is a natural hormone in your body, triggered when you eat. It works alongside other hormones, such as GIP, PYY, and CKK, to regulate various functions in your body.

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1. Regulating Blood Sugar:
GLP-1 tells your pancreas how much insulin to release and signals the liver to slow down glucose production. This balance is crucial for maintaining healthy blood sugar levels.

2. Slowing Gastric Emptying:
GLP-1 slows down how quickly food leaves your stomach, giving your body enough time to process it and signal satiety to your brain.

3. Reducing Appetite:
GLP-1 also plays a role in reducing appetite by acting on receptors in your brain. This hormone decreases cravings and “food noise”—the constant thoughts about food that occupy your mind.

How GLP-1 Impacts Blood Sugar and Insulin

When you eat, your body releases glucose (sugar) into the bloodstream for energy. Insulin, often called the “fat-storage hormone,” allows this glucose to enter your cells to fuel your body. Any excess glucose is stored in fat cells for future use.

The Role of Insulin

If your body has too much sugar, insulin stores it in fat cells. While this is a natural process, chronically elevated insulin levels can lead to various complications, including heart disease, kidney damage, and nerve issues. Whether you’re diabetic or not, it’s essential to manage your sugar and insulin levels.

GLP-1 helps your pancreas release the right amount of insulin for the meal you just ate.

GLP-1 and Weight Management

Your liver releases glucose throughout the day to ensure your cells have enough fuel. GLP-1 helps regulate blood sugar by slowing down glucose release from the liver since you have sugar from your meal. This process ensures that your cells have the right amount of energy without overwhelming your body with too much sugar.

The Risks of Elevated Insulin and Blood Sugar

Consistently high levels of sugar and insulin can cause significant health issues. Shockingly, 80% of US adults are at risk for diabetes due to dietary habits leading to poor sugar and insulin management.[/fusion_text][fusion_builder_row_inner][fusion_builder_column_inner type=”1_2″ type=”1_2″ layout=”1_2″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” column_tag=”div” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ lazy_load=”avada” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” background_slider_skip_lazy_loading=”no” background_slider_loop=”yes” background_slider_pause_on_hover=”no” background_slider_slideshow_speed=”5000″ background_slider_animation=”fade” background_slider_direction=”up” background_slider_animation_speed=”800″ sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” absolute=”off” filter_type=”regular” filter_hover_element=”self” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ transform_type=”regular” transform_hover_element=”self” transform_scale_x=”1″ transform_scale_y=”1″ transform_translate_x=”0″ transform_translate_y=”0″ transform_rotate=”0″ transform_skew_x=”0″ transform_skew_y=”0″ transform_scale_x_hover=”1″ transform_scale_y_hover=”1″ transform_translate_x_hover=”0″ transform_translate_y_hover=”0″ transform_rotate_hover=”0″ transform_skew_x_hover=”0″ transform_skew_y_hover=”0″ transition_duration=”300″ transition_easing=”ease” scroll_motion_devices=”small-visibility,medium-visibility,large-visibility” animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ last=”false” border_position=”all” first=”true” min_height=”” link=””][fusion_text animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky”]

Understanding GLP-1 Agonists

GLP-1 agonists are medications designed to mimic the natural GLP-1 hormone in your body. However, they don’t work exactly like the natural hormone.

The Difference Between Natural GLP-1 and Agonists

While natural GLP-1 slows gastric emptying, it doesn’t slow down the gut itself. On the other hand, pharmaceutical mimics (GLP-1 agonists) tend to have this effect. These medications can be helpful for weight loss, but it’s essential to understand that they are not a perfect replica of the body’s natural processes.

[/fusion_text][/fusion_builder_column_inner][fusion_builder_column_inner type=”1_2″ type=”1_2″ layout=”1_2″ align_self=”auto” content_layout=”column” align_content=”flex-start” valign_content=”flex-start” content_wrap=”wrap” center_content=”no” column_tag=”div” target=”_self” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” order_medium=”0″ order_small=”0″ hover_type=”none” border_style=”solid” box_shadow=”no” box_shadow_blur=”0″ box_shadow_spread=”0″ background_type=”single” gradient_start_position=”0″ gradient_end_position=”100″ gradient_type=”linear” radial_direction=”center center” linear_angle=”180″ lazy_load=”avada” background_position=”left top” background_repeat=”no-repeat” background_blend_mode=”none” background_slider_skip_lazy_loading=”no” background_slider_loop=”yes” background_slider_pause_on_hover=”no” background_slider_slideshow_speed=”5000″ background_slider_animation=”fade” background_slider_direction=”up” background_slider_animation_speed=”800″ sticky=”off” sticky_devices=”small-visibility,medium-visibility,large-visibility” absolute=”off” filter_type=”regular” filter_hover_element=”self” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″ transform_type=”regular” transform_hover_element=”self” transform_scale_x=”1″ transform_scale_y=”1″ transform_translate_x=”0″ transform_translate_y=”0″ transform_rotate=”0″ transform_skew_x=”0″ transform_skew_y=”0″ transform_scale_x_hover=”1″ transform_scale_y_hover=”1″ transform_translate_x_hover=”0″ transform_translate_y_hover=”0″ transform_rotate_hover=”0″ transform_skew_x_hover=”0″ transform_skew_y_hover=”0″ transition_duration=”300″ transition_easing=”ease” scroll_motion_devices=”small-visibility,medium-visibility,large-visibility” animation_direction=”left” animation_speed=”0.3″ animation_delay=”0″ last=”true” border_position=”all” first=”false” min_height=”” link=””][fusion_code]PGRpdiBjbGFzcz0iX2Zvcm1fNDIiPjwvZGl2PjxzY3JpcHQgc3JjPSJodHRwczovL3RoZXdob2xleW91LmFjdGl2ZWhvc3RlZC5jb20vZi9lbWJlZC5waHA/aWQ9NDIiIHR5cGU9InRleHQvamF2YXNjcmlwdCIgY2hhcnNldD0idXRmLTgiPjwvc2NyaXB0Pg==[/fusion_code][/fusion_builder_column_inner][/fusion_builder_row_inner][fusion_text hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” animation_direction=”left” animation_speed=”0.3″]

[fusion_imageframe image_id=”3174|fusion-600″ aspect_ratio=”” custom_aspect_ratio=”100″ aspect_ratio_position=”” skip_lazy_load=”” lightbox=”no” gallery_id=”” lightbox_image=”” lightbox_image_id=”” alt=”GLP-1 weight loss medications ” link=”” linktarget=”_self” max_width=”” sticky_max_width=”” align_medium=”none” align_small=”none” align=”none” mask=”” custom_mask=”” mask_size=”” mask_custom_size=”” mask_position=”” mask_custom_position=”” mask_repeat=”” style_type=”” blur=”” stylecolor=”” hover_type=”none” magnify_full_img=”” magnify_duration=”120″ scroll_height=”100″ scroll_speed=”1″ margin_medium=”” margin_small=”” bordersize=”” bordercolor=”” borderradius=”” z_index=”” caption_style=”off” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title=”” caption_text=”” caption_title_tag=”2″ caption_background_color=”” caption_border_color=”” caption_overlay_color=”” animation_type=”” animation_direction=”left” animation_color=”” animation_speed=”0.3″ animation_delay=”0″ animation_offset=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”” id=”” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″]https://healthwithhashimotos.com/wp-content/uploads/2024/09/7-600×338.jpg[/fusion_imageframe]Names of GLP-1 Medications

One of the most common GLP-1 medications is semaglutide, which is available under brand names like Ozempic, Wegovy, and Rybelsus. Rybelsus is the oral version, whereas the others are injectable.

Other GLP-1 agonist medications include:
– Liraglutide: marketed as Saxenda and Victoza
– Tirzepatide: known as Mounjaro, which impacts both GLP-1 and GIP hormones
– Exenatide: available as Byetta and Bydureon
– Dulaglutide: sold as Trulicity
– Lixisenatide: known as Adlyxin
– Albiglutide: marketed as Tanzeum
– Efpeglenatide

The Benefits of GLP-1 Medications

Despite the high cost, many people turn to these medications because of the benefits, especially in terms of weight loss and blood sugar regulation. A study from Diabetes Daily compared these medications across several key factors, such as:
– A1c reduction: This lab value indicates blood sugar balance over the past 90 days.
– Weight loss: Participants lost between 5 and 28 pounds.
– Delivery form: Most GLP-1 medications are injectables, with Rybelsus being the only oral option.

[fusion_imageframe image_id=”3175|fusion-600″ aspect_ratio=”” custom_aspect_ratio=”100″ aspect_ratio_position=”” skip_lazy_load=”” lightbox=”no” gallery_id=”” lightbox_image=”” lightbox_image_id=”” alt=”Chart of Benefits of GLP-1 weight loss medications ” link=”” linktarget=”_self” max_width=”” sticky_max_width=”” align_medium=”none” align_small=”none” align=”none” mask=”” custom_mask=”” mask_size=”” mask_custom_size=”” mask_position=”” mask_custom_position=”” mask_repeat=”” style_type=”” blur=”” stylecolor=”” hover_type=”none” magnify_full_img=”” magnify_duration=”120″ scroll_height=”100″ scroll_speed=”1″ margin_medium=”” margin_small=”” bordersize=”” bordercolor=”” borderradius=”” z_index=”” caption_style=”off” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title=”” caption_text=”” caption_title_tag=”2″ caption_background_color=”” caption_border_color=”” caption_overlay_color=”” animation_type=”” animation_direction=”left” animation_color=”” animation_speed=”0.3″ animation_delay=”0″ animation_offset=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”” id=”” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″]https://healthwithhashimotos.com/wp-content/uploads/2024/09/9-600×338.jpg[/fusion_imageframe]

The Risks and Side Effects of GLP-1 Medications

One of my core messages is that you are your best advocate. Understanding the risks and benefits of any treatment allows you to make the best decision for your health. GLP-1 medications are no exception, and they do come with guaranteed and potential risks.

Serious Side Effects

– Death: While rare, over 160 people have died related to these medications.

– Severe reactions: In 2018, there were 62,000 reported reactions to GLP-1 medications. Of these, 10,000 were severe, meaning they required hospitalization or resulted in death. However, many adverse reactions go unreported, so the actual number may be much higher.

Muscle and Bone Loss

The most common issue with GLP-1 medications is muscle loss. In fact, this side effect seems to be guaranteed if you use these medications.

Ideally, weight loss should come from fat, not muscle, as muscle supports your metabolism and overall strength. Unfortunately, on GLP-1 medications, people lose 60% of their muscle and only 40% of their fat. This loss in muscle lowers your metabolic rate, and when patients regain weight after stopping the medication, it often comes back as fat, not muscle.

So if you lose 10 pounds, 6 of those were muscle and 4 were fat. If/when you regain weight, all 10 will be fat.

Additionally, patients may experience bone density loss, which is more pronounced with GLP-1 medications compared to other weight loss methods.

Gastrointestinal Issues

Common side effects related to the gastrointestinal system include:
– Vomiting and diarrhea
– Constipation
– Nausea
– Abdominal pain

These issues stem from how the medication slows down gastric emptying, and they are prevalent across most users.

Organ Complications

Use of GLP-1 medications can also impact critical organs, leading to problems in the:
– Pancreas
– Thyroid
– Kidneys

These complications are rare but serious, and they should be part of the consideration when weighing the benefits against the risks.

[fusion_imageframe image_id=”3177|fusion-600″ aspect_ratio=”” custom_aspect_ratio=”100″ aspect_ratio_position=”” skip_lazy_load=”” lightbox=”no” gallery_id=”” lightbox_image=”” lightbox_image_id=”” alt=”” link=”” linktarget=”_self” max_width=”” sticky_max_width=”” align_medium=”none” align_small=”none” align=”none” mask=”” custom_mask=”” mask_size=”” mask_custom_size=”” mask_position=”” mask_custom_position=”” mask_repeat=”” style_type=”” blur=”” stylecolor=”” hover_type=”none” magnify_full_img=”” magnify_duration=”120″ scroll_height=”100″ scroll_speed=”1″ margin_medium=”” margin_small=”” bordersize=”” bordercolor=”” borderradius=”” z_index=”” caption_style=”off” caption_align_medium=”none” caption_align_small=”none” caption_align=”none” caption_title=”” caption_text=”” caption_title_tag=”2″ caption_background_color=”” caption_border_color=”” caption_overlay_color=”” animation_type=”” animation_direction=”left” animation_color=”” animation_speed=”0.3″ animation_delay=”0″ animation_offset=”” hide_on_mobile=”small-visibility,medium-visibility,large-visibility” sticky_display=”normal,sticky” class=”” id=”” filter_hue=”0″ filter_saturation=”100″ filter_brightness=”100″ filter_contrast=”100″ filter_invert=”0″ filter_sepia=”0″ filter_opacity=”100″ filter_blur=”0″ filter_hue_hover=”0″ filter_saturation_hover=”100″ filter_brightness_hover=”100″ filter_contrast_hover=”100″ filter_invert_hover=”0″ filter_sepia_hover=”0″ filter_opacity_hover=”100″ filter_blur_hover=”0″]https://healthwithhashimotos.com/wp-content/uploads/2024/09/11-600×338.jpg[/fusion_imageframe]These GLP-1 agonists do have side effects. While they carry so much hope and promise, they are impacting a lot of people. We want their benefits, but we have to acknowledge the risks. It’s natural to think, “That won’t happen to me,” but unfortunately, these side effects do happen—and they happen to a lot of people. The muscle loss side effect seems to impact EVERYONE who uses any of the GLP-1 Agonists.

Are GLP-1 Agonists Right for You?

As I mentioned earlier, it’s always about weighing the benefits versus the risks. Are the benefits of GLP-1 agonists worth the risks? Initially, I thought maybe they were. But after seeing more data, I can no longer say that. The benefits do not outweigh the risks, especially because, in the next few episodes, I’ll be sharing how you can safely activate your body’s natural GLP-1.

Remember, these medications are just mimics—they mimic the GLP-1 that God already gave you and how your body is designed to function. So stay tuned, because in the coming episodes, we’ll talk about how you can naturally activate your GLP-1 to lose weight in a way that aligns with your body’s own processes.

A Natural Alternative: The MindBody GLP-1 System™

The good news? You don’t need pharmaceutical drugs to activate GLP-1 naturally. The MindBody GLP-1 System™ is a patent-pending, clinically backed system designed to increase your body’s own GLP-1 by 140% on average—without the dangerous side effects.

82% of users took back control of their relationship with food

95% experienced decreased sugar cravings

Weight loss of up to 25 lbs. in 12 weeks (1–2 lbs. per week)

100% of those who lost weight retained muscle

Up to 27% reduction in visceral fat

Rather than overriding your body’s biology like pharmaceuticals, MindBody GLP-1 supports natural hunger hormone balance, helping you reshape your relationship with food for sustainable weight loss.

Get your MindBody GLP-1 System here (affiliate link) the benefits increase when you combine it with the Protandim Nrf2. It’s called the “Healthy Weight Stack.”

Update: Listen to this interview where Jenny Crane and I talk about the MindBody GLP-1 System that increases your GLP-1 production naturally.

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